Building Strategies into QBF Proofs

Strategy extraction is of great importance for quantified Boolean formulas (QBF), both in solving and proof complexity. So far in the QBF literature, strategy extraction has been algorithmically performed from proofs. Here we devise the first QBF system where (partial) strategies are built into the proof and are piecewise constructed by simple operations along with the derivation. This has several advantages: (1) lines of our calculus have a clear semantic meaning as they are accompanied by semantic objects; (2) partial strategies are represented succinctly (in contrast to some previous approaches); (3) our calculus has strategy extraction by design; and (4) the partial strategies allow new sound inference steps which are disallowed in previous central QBF calculi such as Q-Resolution and long-distance Q-Resolution. The last item (4) allows us to show an exponential separation between our new system and the previously studied reductionless long-distance resolution calculus. Our approach also naturally lifts to dependency QBFs (DQBF), where it yields the first sound and complete CDCL-style calculus for DQBF, thus opening future avenues into CDCL-based DQBF solving

Approximate automata for omega-regular languages

Automata over infinite words, also known as ω -automata, play a key role in the verification and synthesis of reactive systems. The spectrum of ω -automata is defined by two characteristics: the acceptance condition (e.g. Büchi or parity) and the determinism (e.g., deterministic or nondeterministic) of an automaton. These characteristics play a crucial role in applications of automata theory. For example, certain acceptance conditions can be handled more efficiently than others by dedicated tools and algorithms. Furthermore, some applications, such as synthesis and probabilistic model checking, require that properties are represented as some type of deterministic ω -automata. However, properties cannot always be represented by automata with the desired acceptance condition and determinism. In this paper we study the problem of approximating linear-time properties by automata in a given class. Our approximation is based on preserving the language up to a user-defined precision given in terms of the size of the finite lasso representation of infinite executions that are preserved. We study the state complexity of different types of approximating automata, and provide constructions for the approximation within different automata classes, for example, for approximating a given automaton by one with a simpler acceptance condition

Integrating Signals from the T-Cell Receptor and the Interleukin-2 Receptor

T cells orchestrate the adaptive immune response, making them targets for immunotherapy. Although immunosuppressive therapies prevent disease progression, they also leave patients susceptible to opportunistic infections. To identify novel drug targets, we established a logical model describing T-cell receptor (TCR) signaling. However, to have a model that is able to predict new therapeutic approaches, the current drug targets must be included. Therefore, as a next step we generated the interleukin-2 receptor (IL-2R) signaling network and developed a tool to merge logical models. For IL-2R signaling, we show that STAT activation is independent of both Src- and PI3-kinases, while ERK activation depends upon both kinases and additionally requires novel PKCs. In addition, our merged model correctly predicted TCR-induced STAT activation. The combined network also allows information transfer from one receptor to add detail to another, thereby predicting that LAT mediates JNK activation in IL-2R signaling. In summary, the merged model not only enables us to unravel potential cross-talk, but it also suggests new experimental designs and provides a critical step towards designing strategies to reprogram T cells